Where Molecules Meet Air: The Science of Nasal Delivery Pathways
Where Molecules Meet Air: The Science of Nasal Delivery Pathways
At AERIS Biosciences™, nasal delivery is more than a route — it’s a scientific frontier. It’s where air meets molecule, where chemistry meets physiology, and where modern formulation science explores one of the most dynamic environments in research.
The nasal cavity is uniquely positioned for groundbreaking laboratory investigation. Its architecture — a highly vascular region paired with direct neural access points — creates a remarkable opportunity for studying how compounds behave when delivered through air-based pathways.
A Gateway Rich With Scientific Potential
Research has shown extraordinary promise in nasal delivery models, highlighting the pathway’s ability to facilitate:
Direct Access to Neural Pathways
Preclinical literature demonstrates the nasal cavity’s connection to the olfactory and trigeminal systems — pathways that allow investigators to explore how molecules can interact with brain-adjacent tissues under controlled laboratory conditions.
Reference: (mdpi.com)
Rapid Interaction With Vascular Tissue
The respiratory region of the nasal cavity offers a rich capillary network, providing scientists with a model for studying fast molecular interactions and uptake dynamics.
Reference: (pmc.ncbi.nlm.nih.gov)
A Versatile Environment for Peptide & Biologic Exploration
Because the nasal system includes mucosal surfaces, epithelial layers, and neural interfaces, it supports a wide range of research questions involving peptides, small molecules, biologics, and novel carriers.
Reference: (mdpi.com)
A Formulator’s Dream: A Dynamic Environment for Discovery
Nasal delivery brings together multiple scientific variables — each offering its own layer of possibility.
Spray Dynamics & Deposition Patterns
Researchers can study how spray angle, droplet size, and formulation physics influence deposition across nasal structures.
Reference: (arxiv.org)
Molecular Stability & Interaction Studies
The nasal environment provides a powerful model for understanding peptide integrity, interactions with mucosal membranes, and biochemical signaling potentials in controlled settings.
Reference: (pmc.ncbi.nlm.nih.gov)
Advanced Nose-to-Brain Investigation
Multiple preclinical studies highlight the nasal cavity’s unique role in enabling direct access to central structures — a breakthrough area for research involving peptides, neuro-active molecules, and mitochondrial targets.
Reference: (frontiersin.org)
The AERIS™ Approach: Precision Meets Airflow
AERIS Biosciences™ develops nasal-format research compounds with an uncompromising focus on:
High purity and verified identity
Consistent spray characteristics
Optimized formulation stability
Rigorous analytical documentation (COA + MSDS)
Research-dedicated design from molecule to bottle
Our goal is to provide researchers with the most refined materials available for nasal pathway investigation — so every experiment starts with confidence, clarity, and precision.
The Future of Air-Based Delivery Science
As scientific interest in non-injectable delivery continues to rise, nasal-based research is poised to lead the next wave of discovery. The combination of neural proximity, vascular access, and anatomical accessibility creates a foundation unlike any other route.
At AERIS™, we are committed to advancing this frontier — supplying the materials that empower researchers to explore, innovate, and redefine what’s possible when molecules meet air.
Research Use Only Disclaimer
All information and references above relate to preclinical, in-vitro, or laboratory research. AERIS Biosciences™ products are for laboratory research use only and are not approved for human or veterinary use.
Key References for Further Reading:
Alabsi W., Eedara BB., Encinas-Basurto D., Polt R., Mansour HM. Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols. Pharmaceutics. 2022;14(9):1870. Experts at Arizona+1
Huang Q. et al. Research Progress in Brain-Targeted Nasal Drug Delivery. Frontiers in Aging Neuroscience. 2024. Frontiers
Gandhi S., et al. Nasal Delivery to the Brain: Harnessing Nanoparticles for Intranasal Delivery. MDPI. 2024. PMC
Luo D., et al. A Comprehensive Review of Advanced Nasal Delivery. (2024) – ScienceDirect. ScienceDirect
Xu K., et al. Nose-to-Brain Delivery of Nanotherapeutics: Transport Mechanisms, Challenges and Future Perspectives. Wiley Online Library. 2024. PubMed
